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Giuseppina Di Stefano Selected Research

Lactate Dehydrogenase 5

1/2022Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme.
1/2021Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment.
1/2019Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir.
1/2018The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells.
7/2017LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells.
1/2017Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells.
11/2016Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A.
8/2015Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors.
9/2013Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1.
1/2013Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells.

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Giuseppina Di Stefano Research Topics

Disease

20Neoplasms (Cancer)
01/2021 - 08/2005
12Hepatocellular Carcinoma (Hepatoma)
07/2017 - 06/2004
6Alzheimer Disease (Alzheimer's Disease)
02/2017 - 01/2007
4Vitamin E Deficiency
06/2004 - 05/2002
3Mitochondrial Diseases (Mitochondrial Disease)
01/2015 - 06/2006
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2013 - 06/2006
3Neoplasm Micrometastasis
07/2010 - 05/2002
3Epilepsy (Aura)
07/2010 - 06/2008
2Lactic Acidosis
08/2022 - 01/2022
2Pancreatic Neoplasms (Pancreatic Cancer)
12/2020 - 03/2019
2Burkitt Lymphoma (Burkitt's Lymphoma)
07/2015 - 09/2013
2Amyloid Plaque
12/2010 - 01/2007
1Fatigue
08/2022
1Liver Neoplasms (Liver Cancer)
01/2022
1Ovarian Neoplasms (Ovarian Cancer)
03/2019
1Breast Neoplasms (Breast Cancer)
01/2019
1Carcinogenesis
07/2017
1Inflammation (Inflammations)
01/2017
1Colonic Neoplasms (Colon Cancer)
01/2017
1Frailty
12/2015
1Lymphoma (Lymphomas)
07/2015
1Cardiovascular Diseases (Cardiovascular Disease)
03/2014
1Cardiotoxicity
11/2011
1Encephalitis (Encephalitis, Rasmussen)
12/2010
1Disease Progression
12/2010
1Neuroinflammatory Diseases
10/2010
1Hepatitis
07/2010
1Traumatic Brain Injuries (Traumatic Brain Injury)
07/2010
1Hypoxia (Hypoxemia)
07/2010
1Obesity
07/2010
1Ischemia
07/2010

Drug/Important Bio-Agent (IBA)

10L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
08/2022 - 02/2012
10Lactate Dehydrogenase 5IBA
01/2022 - 01/2013
8Pharmaceutical PreparationsIBA
07/2015 - 10/2005
7Doxorubicin (Adriamycin)FDA LinkGeneric
07/2010 - 06/2004
7Human Serum AlbuminFDA LinkGeneric
10/2009 - 06/2004
6Lactic Acid (Lactate)FDA LinkGeneric
08/2022 - 08/2015
6EnzymesIBA
08/2022 - 06/2006
5Glucose (Dextrose)FDA LinkGeneric
01/2021 - 02/2012
5Biomarkers (Surrogate Marker)IBA
02/2017 - 10/2010
5Asialoglycoprotein ReceptorIBA
07/2010 - 06/2004
4Pyruvic Acid (Pyruvate)IBA
08/2022 - 01/2017
4Adenosine Triphosphate (ATP)IBA
01/2021 - 04/2011
4galloflavinIBA
07/2017 - 09/2013
3Mitochondrial DNA (mtDNA)IBA
02/2017 - 04/2014
3NAD (NADH)IBA
08/2015 - 01/2013
3AlbuminsIBA
02/2008 - 10/2005
2Antineoplastic Agents (Antineoplastics)IBA
01/2021 - 12/2004
2Cisplatin (Platino)FDA LinkGeneric
01/2021 - 07/2015
2olaparibIBA
12/2020 - 03/2019
2Protein Isoforms (Isoforms)IBA
01/2018 - 01/2017
2CytokinesIBA
01/2017 - 10/2010
2Biological ProductsIBA
09/2013 - 05/2002
2Oxidoreductases (Dehydrogenase)IBA
04/2011 - 01/2010
2Floxuridine (FUdR)FDA LinkGeneric
07/2010 - 01/2003
2Electron Transport Complex IV (Cytochrome c Oxidase)IBA
05/2008 - 06/2006
2Amyloid beta-PeptidesIBA
03/2008 - 01/2007
2CeroidIBA
05/2002 - 05/2002
1Oxygen (Dioxygen)IBA
08/2022
1Lactate DehydrogenasesIBA
08/2022
1Citric Acid (Citrate)FDA LinkGeneric
08/2022
1Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2021
1DNA (Deoxyribonucleic Acid)IBA
01/2021
1Phosphotransferases (Kinase)IBA
01/2018
1Enzyme Inhibitors (Inhibitors, Enzyme)IBA
07/2017
1Heat-Shock Proteins (Heat-Shock Protein)IBA
07/2017
1Interleukin-17 (Interleukin 17)IBA
01/2017
1LipidsIBA
03/2014
1AntioxidantsIBA
03/2014
1Sorafenib (BAY 43-9006)FDA Link
11/2011
1Oxamic AcidIBA
04/2011
1N-Acetylneuraminic Acid (Sialic Acid)IBA
12/2010
1Acute-Phase Proteins (Acute-Phase Protein)IBA
12/2010
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
10/2010
1Phospholipases (Phospholipase)IBA
10/2010
1Antiviral Agents (Antivirals)IBA
07/2010
1Vidarabine PhosphateIBA
07/2010
1AcidsIBA
01/2010
1Drug CarriersIBA
10/2009
1Peptides (Polypeptides)IBA
03/2008
1Amyloid (Amyloid Fibrils)IBA
01/2007
1Proteins (Proteins, Gene)FDA Link
01/2007
1Succinate Dehydrogenase (Fumarate Reductase)IBA
06/2006
1Diethylnitrosamine (N-Nitrosodiethylamine)IBA
10/2005
1diethylamineIBA
08/2005
1GAP-43 Protein (GAP 43 Protein)IBA
06/2004
1Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
11/2002
1lipopigmentsIBA
05/2002
1LipofuscinIBA
05/2002
1nasIBA
05/2002

Therapy/Procedure

5Drug Therapy (Chemotherapy)
07/2015 - 01/2003
3Therapeutics
03/2014 - 02/2010
3Ketogenic Diet
07/2010 - 06/2008